Points of interest:
Conjunto monumental San Francisco. The church dates back from the 1570s and was devoted to San Francis, since the Franciscan order was the first to settle in the area. Hence the city's official name: San Francisco de Quito.
Museo del Banco Central, you'll find perhaps Ecuador's most renowned museum with different rooms, devoted to pre-Columbian, Colonial and gold works of art, among other topics.
Casa de la Cultura shows a patchwork of local artists.
Museo de la Ciudad. A lovely museum with two floors encircling two quiet courtyards, the "Museo de la Ciudad" provides more of a social history of Ecuador than other museums in Quito. Re-enacted scenes from daily life of Ecuador's citizens through the years include a hearth scene from a 16th-century home, a battle scene against the Spanish, and illustrations of the building of Iglesia de San Francisco church.
Teleferico. This is the world's second-highest cable car.
Botanical Gardens. It's a wonderful escape from the city, with all of Ecuador's ecosystems represented with a wide variety of flora. You can take a guided tour or just wander. The highlight for many people are the two glassed-in orchidariums.
Museo Mindalae. An extremely original project in the north part of the Mariscal District, this museum provides an 'ethno-historical' view of Ecuador's amazingly rich cultural diversity. You can find out about the country's different peoples, from the coast to the Andes to the Amazon, and their crafts in a specially-built and designed structure.
Museo Guayasamin. This musueum houses the collection of Ecuador's most renowned contemporary artists, Oswaldo Guayasamin. It has a fine collection of pre-Colombian, colonial and independence art, as well as housing many of the artist's works.
Calle de la Ronda. This street in the Old Town was restored by Municipality and FONSAL in 2007. It was transformed with the help and cooperation of the local residents. It's a romantic cobbled street just off the Plaza Santo Domingo (or it can be reached via Garcia Moreno by the City Museum).