One of the symbols of Rome is the Colosseum (70–80 AD), the largest amphitheatre ever built in the Roman Empire. Originally capable of seating 60,000 spectators, it was used for gladiatorial combat.
In Old Rome you must see the Pantheon, which is amazingly well preserved considering it dates back to 125 AD. There is a hole constructed in the ceiling so it is an interesting experience to be there when it is raining.
Castel Sant' Angelo, built as a Mausoleum for the Emperor Hadrian. This is connected by a covered fortified corridor to the Vatican and served as a refuge for Popes in times of trouble.
The Baths of Diocletian are opposite the entrance to the main railway station, Termini. The National Museum of Rome stands in the South-West corner of the Baths complex and has an enormous collection of Roman scultures and other artifacts. But this is just one of numerous museums devoted to ancient Rome, including those of the Capitoline Hill.
Major churches of Rome: St Peter’s, St Paul’s Outside the Walls, Santa Maria Maggiore and San Giovanni. All pilgrims to Rome are expected to visit these four basilicas, together with San Lorenzo fuori le mura, Santa Croce in Gerusalemme, and the Sanctuary of Divino Amore.
Villa Borghese in Campo Marzio, where there is a cluster of art museums. Galleria Borghese houses a previously private art collection of the Borghese family, Museo Nazionale di Villa Giulia is home of the world's largest Etruscan art collection, and Galleria Nazionale d'Arte Moderna houses many Italian masterpieces as well as a few pieces by artists such as Cézanne, Degas, Monet and Van Gogh. The Capitoline Museums in the Colosseo district opens their doors to the city's most important collection of antique Roman and Greek art and sculptures. Visit the Galleria d'Arte Antica, housed in the Barberini palace in the Modern center, for Italian Renaissance and Baroque art. A visit to Rome is not complete without a trip to the Vatican Museum.
Trevi Fountain, surely a part of everyone's Roman holiday. Visitors are always amazed that such a big and famous fountain is tucked away in a small piazza in the middle of side streets.